What is a sign of sepsis becoming systemic?

A sign of sepsis becoming systemic is altered mental status. In the context of sepsis, as the body responds to infection, it can result in a state of systemic inflammatory response, which may impair brain function. Patients can exhibit confusion, disorientation, or decreased alertness, which are indications that the body's systems are being severely affected.

As sepsis progresses, the physiological response can lead to inadequate blood flow and oxygen delivery to various organs, including the brain. This is why altered mental status is a critical sign to monitor; it often signifies that the sepsis is becoming more severe, potentially leading to septic shock and multiple organ dysfunction if not addressed promptly.

Other options relate to bodily functions that would typically show signs of stress or improve in response to infection. For instance, a lowered heart rate, high blood pressure, or lowered respiratory rate may not accurately reflect the systemic nature of sepsis in the same direct manner as altered mental status does.